4. Charlotte Dessaux

Project Title and Work Package(s): Role of the L. monocytogenes stressosome during intracellular pathogenesis (WP2, WP3, WP5)

Objectives: To: (1) determine the role played stressosome components in the invasion and intracellular life cycle of L. monocytogenes; (2) measure the influence of the stress sensing via the stressosome on the L. monocytogenes proteome in the vacuole and cytoplasm of the host cell; (3) Determine the influence of the stressosome on the cell envelope structure of L. monocytogenes (protein and glycolipid).

Expected Results: A comprehensive understanding of the role of stress sensing via the stressosome on the intracellular behaviour of L. monocytogenes. A full description of the role of the stressosome in regulating the proteome and cell surface properties during the intracellular stage of infections.

Personal Statement

I come from France where I have been graduated in Master 2 Structural and Functional Biochemistry at Université Paul Sabatier Toulouse (June 2017). I did master internships at The Institute of Pharmacology and Structural Biology (Toulouse) where I studied the role and the structure-function relationships of mycobacterial cell envelope lipids and the stimulation of CD1-restricted T cells. Since September 2017, I joined Centro Nacional de Biotecnología-CSIC in Madrid in order to investigate the role of Listeria monocytogenes during intracellular pathogenesis.