12. Manisha Pandey

//12. Manisha Pandey
12. Manisha Pandey 2018-01-11T10:52:14+00:00

Project Description

Manisha Pandy

Manisha Pandey

Early Stage Researcher 12,
University of Dundee

Project Title and Work Package(s): Genetic study of the molecular mechanisms of sensory perception in B. subtilis. (WP 4)

Objectives: To: (1) generate σB reporter fusions that allow the quantification of stressosome-dependent stress sensing in B subtilis; (2) Use random transposon mutagenesis and targeted mutagenesis of RsbR and its paralogues to identify mutants with defective stress sensing (either locked-on or blind); (3) develop single-cell and population based mathematical models that account for the stress sensing behaviour of B. subtilis in collaboration with participant #UC.

Expected Results: The development of stress-sensing biosensors for B. subtilis, which will be available to the Network. Identification of novel factors influencing stressosome-mediated sensing in B. subtilis and a genetic definition of residues important for sensing in RsbR and its paralogues. A model describing the molecular mechanisms of stress sensing in Bacillus.

Personal Statement

I am Manisha Pandey from the land of Taj Mahal and Mars orbital Mission – India. I did my Bachelor’s in Zoology(h) from University of Delhi, India and my Master’s in Life Sciences from Jawaharlal Nehru University, India.

In my master’s dissertation I worked on a protein  involved in the phagocytic process of pathogen Entamoeba histolytica. Later, I briefly  worked in a lab working on chondrogenic differentiation of human bone marrow Mesenchymal Stem Cells.

I am currently recruited as an ESR in University of Dundee. My primary interest are infection biology and development biology. Apart from science, I like interacting with new people, going on nature walks, reading, swimming and pondering over the unity and diversity of life.

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