2. Light-induced stress-regulation
We have identified a gene encoding a blue-light receptor to be important for various phenotypes, such as the formation of consolidation zones. The blue-light receptor is part of an intricate system of sigma-factor regulation through a large protein complex known as the stressosome (Tiensuu et al., 2013). Current studies try to molecularly understand how the blue-light receptor interacts with the stressosome.
3. Identification of RNA-dependent and independent antibacterial drugs
The activity of the main regulator of virulence in L. monocytogenes, PrfA, has recently been shown to be stimulated by glutathione (Hall et al., 2016). We have also identified small compounds able to block PrfA-activity and hence the ability of L. monocytogenes to cause infection (Good et al,. 2016).